I made 2 test combi hiv 4th gen ,3 month and 4 month.I have a question,if my body dont produce antibodies the antigen is still there detectable.I asked because i am concern about late seroconversion,still i have symptoms,pain in my body,loss of weight
Thank you for your inquiry. From what we gather from the question, you were asking about the accuracy of the 4th Generation HIV Ab/Ag test and the possibility of late seroconversion.
It typically takes 2 weeks for your immune system to start producing antibodies to HIV. By 4-6 weeks post-exposure most people (99%) will have produced enough antibodies to be detectable via an HIV antibody test (1). This percentage increases up to 99.9% of people newly infected with HIV will be detectable after 3 months post-exposure (1). At this time the results are deemed completely conclusive. Late seroconversion, also known as delayed seroconversion, is very unlikely and has only been described in the literature a limited amount of times using very old (>20 years) and less sensitive HIV testing techniques (2). The possibility of being a delayed seroconverter is very, very low.
Recommendation: No need for follow-up HIV test with the scenario provided, refer to a physician for other health related questions.
AIDS Vancouver Helpline/Online, Marie