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I did 2 HIV test, 1st test after exposure of 5 months and 2nd after 1 year of 1st test. Both were negative. Are these results conclusive?

Question: 

Hello Sir, i had a girlfriend, who was HIV positive, and after our break up she told me that she is HIV positive. We had sex alot of times but most of time i used Condoms. But still i tested myself on sep 2016, it was an Antibody and antigen p24 test. The report was nonreactive. Again after 1 year i tested myself cause i was abit confused due to having a wart near my genital ... test was same Antibody and antigen p24 test. Again the report was nonreactive. can i rely on these reports or again i should go for a HIV test?

Answer: 

Hello,

Thank you for your inquiry. From what we gather from the question, you were asking about the reliability of the results from the test you received both in Sept 2016 and one year post exposure. From our understanding you did receive the P24 Antigen test within the recommended window period following your exposure. The P24 Antigen test is most effective ONLY within the first couple of weeks following exposure (once the body starts producing antibodies, this antigen is no longer detectable). If you received the P24 Antigen test within the recommended window period of testing, official guidelines suggest re-testing at 12 weeks post exposure. Although the P24 Antigen test you received resulted in a non reactive result, you were responsible in your action of taking a follow up test. With this in mind, the P24 Antigen test is again most effective in detecting the P24 protein associated with HIV only within the first few weeks following exposure. Any further testing five to six weeks and above should be directed to either a Western Blot or 4th Generation EIA test (see link below). In this case, we cannot confirm the reliability of the nonreactive results from the P24 test administered one year post exposure due to the nature of this particular test.

Recommendation: Refer to Physician for 4th Generation/Western Blot test for a more conclusive result. If you are continuously engaging in high risk activity there are biomedical approaches such as PrEP and PEP that help lower your risk of acquiring HIV.

Regards, AIDS Vancouver Helpline/Online, Cody