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4th Generation EIA "DUO" Test, Conclusive?

Question: 

Hello Doctor, I am sincerely hoping you can give me a sense of relief because the past 2 months have been a complete NIGHTMARE for me. Let me start by giving you the full story. On May 5 I had unprotected oral sex with a guy that lasted for about 2- 3 minutes. he did not ejaculate but I am unsure ofthe pre-semen. He then penetrated me unprotected for about 1-2 minutes in which I stopped him and made him put on a condom. After we were done, he removed the condom and cleaned himself up he and then penetrated me again for about 1-2 minutes.Which I again stopped him because he did not have on a condom. I am unsure if any semen or pre-semen entered my body which has me going nuts! about 3 weeks later I had diarrhea. I am lactose intolerant so I sort of thought it could be from that so I did not worry about it. On June 4th The day before my birthday, I noticed I had a sore throat and dry cough with a very low temp. I immediately scheduled a visit with my doctor as I was really nervous. I had a slight fever and asked my doctor to perform an STD test. When I got my results back I tested Syphilis - Negative HEP B - Negative Hep C = Negative HIV = Negative HSV 1 Negative HSV 2 Positive Although I tested positive for HSV 2, I thought I was okay as for the HIV results, however, I read that there was a window period and I would need to retest. As time went on I started to have a very upset stomach gassy bloated and diarrhea. It went away for awhile but occasionally comes back. I went to the dentist because of infected wisdom tooth and they prescribed me Clindamycin which I developed thrush and more diarrhea I was told that this was possibly due to the meds. I also have had dry mouth which I also heard could be from the meds as well. My Period for this month is noticeably lighter than normal which I am freaking out about. I never got a rash or anything or that I have noticed. About a week ago my husband (Yes I am married which I feel HORRIBLE About)started having diarrhea with an upset stomach. I noticed a rash on his knee which looked more like a bruise than a rash it was red and purple with no bumps and very small. He works as a contractor and is always on his knees so he could be from that and his hands are dry which made me worry as well, but he has had no other symptoms. I also noticed that I had a small swollen parotid lymph node (Or so I think)which has since become very very small, almost unnoticeable. I got nervous and decided to go back to the doctor so that she could test for HIV again. The results were still negative. My mouth is dry not and in my opinion not producing any saliva which is a major concern for me. I continuously chew gum to remedy this. I am on Klonopin to help with my anxiety. I have taken many tests to try and ease my mind but I am still unsure. Here is a clear timeline of each test EXPOSURE DATE- May 5 June 6th Lab-4th generation Duo Test Results = Negative June 23rd Lab-4th generation Duo Test Results = Negative June 29th Oraquick Home test Results = Negative July 9th Oraquick Home test Results = Negative July 12th Lab-4th generation Duo Results = Negative Husband took a test as well July 2nd Lab-4th generation Duo Results = Negative The other guy took a test as well July 1st Oraquick Home test Results = Negative, however, I wasn't the when he took it so I dont know the accuracy. less than br/ greater than Doctor, I am truly a nervous wreck at this point because I have been feeling very tired lately as well. Which could be due to the Klonopin but this just as on to my feelings of Anxiety. Can you please please please post and respond??? Sincerely Extreme Panic Attack

Answer: 

Hello,

Thank you for your inquiry. From what we gather from the question, you were asking about the conclusiveness of your 4th Generation EIA Test (Commonly referred to as the "DUO" test).

This "DUO" test detects the p24 antigen on the HIV virus directly as well as antibodies to the virus produced by the body. Due to this combined detection, the window period for the "DUO" test is 4-12 weeks. After 6 weeks, most HIV specialists would consider the "DUO" test conclusive because the test can detect HIV infection in 99% of people after this amount of time (1).

From your question, you stated that you may have been exposed to HIV on May 5th and a "DUO" test was performed for you by a lab on June 6th (4.5 weeks post-exposure), June 23rd (7 weeks post-exposure), July 12th (9.5 weeks post-exposure), and for your husband on July 2nd (8 weeks post-exposure). Most HIV specialists would consider the tests conducted 6 weeks after exposure to be conclusive, thus the negative results from the June 23rd, July 2nd, and July 12th are all conclusive.

References:

1) http://www.catie.ca/en/fact-sheets/testing/hiv-testing-technologies

Recommendation: No need for HIV test with the scenario provided, refer to a physician for other health related questions.

Regards,

AIDS Vancouver Helpline/Online, Marie