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Rizene as PEP drug


Is Rizene alone a good hiv-PEP drug, taken within 48 hours after exposure and testing hiv-negative.



Thank you for your inquiry. From what we gather from the question, you were asking about the effectivness of Rizene as post-exposure prophylaxis (PEP) taken within 48 hours after an exposure.

Rizene is the generic form of the drug Atripla, which consists of three drugs: tenofovir disoproxil fumarate, emtricitabine, and efavirenz (1). The first two of these three drugs are very common and are the sole components of the pre-exposure prophylaxis (PrEP) drug Truvada (1,2). The addition of the third drug in PEP regimens is to account for the possibility of viral resistance to certain drugs, making it more effective in a post-exposure scenario. The third drug included in a PEP regimen varies depending on where you are living, but the third drug in Rizene (efavirenz) is included as one of the WHO recommended drugs if available.

PEP is most effective when taken as soon as possible (within 72 hours) after an exposure for a total of 28 days (4). HIV testing 6 weeks and 3 months after PEP completion are recommended by most physicians and guidelines for completely conclusive results. If you are continuously engaging in high risk activity, accessing PrEP will help lower your risk of acquiring HIV. Refer to your physician for further information.

Recommendation: Refer to a physician for an HIV test 6 weeks and 3 months post-PEP completion.


AIDS Vancouver Helpline/Online, Marie