Anonymous
Hello,

I made 2 test combi hiv 4th gen ,3 month and 4 month.I have a question,if my body dont produce antibodies the antigen is still there detectable.I asked because i am concern about late seroconversion,still i have symptoms,pain in my body,loss of weight
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Anonymous
Hello,

Thank you for your inquiry. From what we gather from the question, you were asking about the accuracy of the 4th Generation HIV Ab/Ag test and the possibility of late seroconversion.

It typically takes 2 weeks for your immune system to start producing antibodies to HIV. By 4-6 weeks post-exposure most people (99%) will have produced enough antibodies to be detectable via an HIV antibody test (1). This percentage increases up to 99.9% of people newly infected with HIV will be detectable after 3 months post-exposure (1). At this time the results are deemed completely conclusive. Late seroconversion, also known as delayed seroconversion, is very unlikely and has only been described in the literature a limited amount of times using very old (>20 years) and less sensitive HIV testing techniques (2). The possibility of being a delayed seroconverter is very, very low.

Recommendation: No need for follow-up HIV test with the scenario provided, refer to a physician for other health related questions.

Regards,

AIDS Vancouver Helpline/Online, Marie
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