Thank you for your inquiry. From what we gather from the question, you were asking about the consequences of not developing antibodies against the p24 antigen.
In regards to symptoms, there should be no change in the way your body develops symptoms in the presence or absence of p24 antibodies. The virus, as well as the other immune responses that would occur, would have the most impact on any symptoms you may experience.
In regards to testing, the lack of antibodies against the p24 antigen is not problematic. HIV 3rd generation tests, and the antibody portion of the 4th generation test, detect antibodies that your body develops in response to an HIV infection. Even if no antibodies to the p24 antigen are produced, the test is able to detect other antibodies against a variety of HIV antigens, such as gp160, gp41, and p31.
Please refer to a healthcare professional for more personalized answers or other health related questions.
AIDS Vancouver Helpline/Online, Marie
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