I had an unprotected vaginal exposure with a female sex worker back in March 2014 and throughout all these years I have developed these following unexplained symptoms below.

Intense Chest pain (facing with 4 years - unexplained)
Intense shoulder pain (facing with 4 years - MRI revealed Cervical Lymphadenopathy)

Trigeminal Neuralgia (facing with 3 years unexplained but I am on medication for that)
Left ear eustachian tube inflammation (facing with 3 years)
Back Burning when back exposed to air or without a shirt (facing with 3 years - unexplained)

Crawling feeling at the back of the right head side (facing with 2 years - unexplained)

Kidney pain (facing with 5 months - unexplained)
and now the left leg pain. (facing with 5 months - unexplained)

All of these health problems mentioned above are still undiagnosed and unexplained.

I tested for HIV 1,2 via fourth-generation Eclia three times (July 2014 and December 2014 and March 2015), results were Non-reactive for all of these three tests above.

but all these symptoms are very serious and concerning cause once they come they never go away even with a bunch of different combinations of medicines.

I have not had another exposure since 2014.

Please reply

Thank you for your inquiry. From what we gather from the question, you were asking about your various undiagnosed and unexplained symptoms/health problems and whether or not they are related to possible HIV acquisition. From the information given, the exposure in March 2014 (vaginal intercourse without a condom) is determined to be High Risk (there is evidence of transmission through these activities and are the majority of cases of transmission). However, given that you have had three 4th-generation HIV tests and have not had another exposure since 2014, I would like to reassure you that you can be considered to be of negative status.

The scenario experienced in March 2014 does meet the three components of the transmission equation (see below). HIV transmission requires the transfer of a HIV positive fluid, coupled with a High, Low, or Negligible Risk activity that provides the HIV virus with direct access to the bloodstream.

However, given that you have not had another exposure since then, you can be considered to be negative. This is because 4th generation HIV tests (such as the ones you've taken) have very high sensitivity and specificity, one that approaches 100% (1). This means that they are very accurate in terms of determining whether or not you are infected with HIV and, if the 4th generation tests is negative, you can be considered uninfected and no further testing needs to be done (2).

In regards to your unexplained symptoms/health concerns, they are not ones that are typical of an HIV infection, nor can symptoms indicate HIV if your tests come back negative. Therefore, I would suggest for you to seek a healthcare professional for your following understandable concerns regarding your health.

Recommendation: Refer to a healthcare professional for any health-related questions.

AIDS Vancouver Helpline/Online, Ryan

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(1) Peters PJ, Westheimer E, Cohen S, et al. Screening Yield of HIV Antigen/Antibody Combination and Pooled HIV RNA Testing for Acute HIV Infection in a High-Prevalence Population. JAMA 2016; 315:682.
(2) Bartlett J, Sax P. Screening and diagnostic testing for HIV infection [Internet]. Uptodate.com. 2018 [cited 28 April 2018].


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